Cancer Treatment Centers in South Dakota

After a Cancer Diagnosis in South Dakota: How to Use This Resource

A cancer diagnosis can bring uncertainty, fear, and many questions for patients and caregivers. People may feel overwhelmed while trying to understand medical information, schedule appointments, and manage work or family responsibilities. In South Dakota, where many communities are rural and spread across long distances, knowing where cancer treatment centers are located can help patients plan more clearly and feel less alone.

This page on South Dakota cancer treatment centers was created to help patients and caregivers understand the range of cancer care options available in the state and nearby regions. It is an educational resource only. It does not provide medical advice, recommend treatments, or suggest that one provider is better than another. Instead, it organizes information so individuals can have informed conversations with qualified healthcare professionals.

Types of Cancer Treatment Centers You May See

As you review the list below, you may notice different types of cancer treatment centers. Some are part of large health systems or academic-affiliated hospitals. Others are community-based cancer centers focused on providing care closer to home.

You may also see pediatric or specialty programs that focus on children, blood disorders, or specific cancer services. Many patients receive care from more than one cancer center over time as their needs change.

How to Use the List Below

The cancer treatment centers in South Dakota are organized into tiers to make the information easier to understand. These tiers describe different care settings and organizational structures, not levels of quality. Some patients begin care locally and later seek referrals or second opinions for specialized services.

Balancing travel distance, daily responsibilities, insurance coverage, and caregiver support is an important part of decision-making. It is common for patients to work with more than one cancer care provider during treatment and follow-up.

Tier 1 – NCI-Designated Cancer Centers

South Dakota does not currently have an in-state National Cancer Institute (NCI)-Designated Cancer Center. South Dakota residents commonly access NCI-designated care in nearby states such as Minnesota, Nebraska, and Iowa, which are listed later in this guide.

Tier 2 – Major Academic & Health-System Cancer Centers

Sanford Cancer Center (Sioux Falls)

Address: 1305 W 18th St, Sioux Falls, SD 57105

Phone: (605) 328-4000

Website: https://www.sanfordhealth.org/medical-services/cancer-care

Avera Cancer Institute (Sioux Falls)

Address: 1325 S Cliff Ave, Sioux Falls, SD 57105

Phone: (605) 322-9000

Website: https://www.avera.org/services/cancer-care/

Monument Health Cancer Care Institute (Rapid City)

Address: 353 Fairmont Blvd, Rapid City, SD 57701

Phone: (605) 755-6000

Website: https://monument.health/services/cancer-care/

Tier 3 – Community & Regional Cancer Centers

Avera McKennan Hospital & University Health Center — Cancer Services (Sioux Falls)

Address: 1325 S Cliff Ave, Sioux Falls, SD 57105

Phone: (605) 322-9000

Website: https://www.avera.org/locations/profile/avera-mckennan-hospital-university-health-center/cancer-care/

Sanford USD Medical Center — Cancer Services (Sioux Falls)

Address: 1305 W 18th St, Sioux Falls, SD 57105

Phone: (605) 328-4000

Website: https://www.sanfordhealth.org/locations/sanford-usd-medical-center/cancer-care

Monument Health Rapid City Hospital — Cancer Care Services (Rapid City)

Address: 353 Fairmont Blvd, Rapid City, SD 57701

Phone: (605) 755-6000

Website: https://monument.health/services/cancer-care/

Tier 4 – Community Oncology Groups & Networks

Midwest Hematology Oncology Specialists (Multiple Locations)

Address: 1305 W 18th St, Sioux Falls, SD 57105

Phone: (605) 328-4000

Website: https://www.sanfordhealth.org/medical-services/cancer-care

Avera Medical Group Oncology & Hematology (Multiple Locations)

Address: 1325 S Cliff Ave, Sioux Falls, SD 57105

Phone: (605) 322-9000

Website: https://www.avera.org/services/cancer-care/

Tier 5 – Pediatric & Specialty Cancer Centers

Sanford Children’s Hospital — Pediatric Hematology & Oncology (Sioux Falls)

Address: 1305 W 18th St, Sioux Falls, SD 57105

Phone: (605) 328-4000

Website: https://www.sanfordchildrens.org/medical-services/pediatric-cancer-care

Avera Children’s Hospital — Pediatric Oncology (Sioux Falls)

Address: 1325 S Cliff Ave, Sioux Falls, SD 57105

Phone: (605) 322-9000

Website: https://www.avera.org/services/childrens/pediatric-cancer-care/

Avera Transplant Institute — Blood & Marrow Transplant Services (Sioux Falls)

Address: 1325 S Cliff Ave, Sioux Falls, SD 57105

Phone: (605) 322-9000

Website: https://www.avera.org/services/transplant/bone-marrow-transplant/

Tier 6 – Nearby Out-of-State Centers of Excellence

Mayo Clinic Comprehensive Cancer Center (Rochester, MN)

Address: 200 1st St SW, Rochester, MN 55905

Phone: (507) 284-0000

Website: https://www.mayoclinic.org/departments-centers/cancer-center

University of Minnesota Masonic Cancer Center (Minneapolis, MN)

Address: 420 Delaware St SE, Minneapolis, MN 55455

Phone: (612) 624-8888

Website: https://cancer.umn.edu

Fred & Pamela Buffett Cancer Center (Omaha, NE)

Address: 987400 Nebraska Medical Center, Omaha, NE 68198

Phone: (402) 559-2100

Website: https://www.nebraskamed.com/cancer

Looking for Additional Cancer Care Providers?

The cancer treatment centers listed on this page are curated and organized into tiers to help patients and caregivers better understand the types of cancer care available to South Dakota residents. This list is not intended to be exhaustive, and some legitimate cancer care providers or programs may not appear here.

If you do not see a cancer treatment center near you, the trusted directories below can help you explore additional cancer care options in South Dakota and surrounding states.

• 
  National Cancer Institute — Find a Cancer Center
  
• American College of Surgeons — CoC Program Finder
• 
  VA Facility Locator
  

Can’t find a cancer treatment center near you? Patients and caregivers may contact cancereducationfoundation.local for guidance in locating additional cancer care resources.

Important Note

This list is provided for educational and informational purposes only. It is intended to help patients and caregivers understand the range of cancer treatment options available and is not a recommendation or endorsement of any specific provider.

While we strive to present a broad and representative overview of cancer treatment centers, this list may not include every cancer care provider or program in the state, and services offered can vary by location.

Patients are encouraged to discuss care options with qualified healthcare professionals and to contact treatment centers directly to confirm services, availability, and suitability for their individual needs.

Disclaimer: This information is for educational purposes only and is not medical advice. Talk to a healthcare provider about questions related to your health.